时间：3月26日 (周四)  18:00-20:00

地点：恕园28号楼205室

主题：文献报告和工作进展

1、工作进展：少突胶质细胞前体细胞的P2Y12受体调控脊髓上行疼痛通路的机制研究

主讲： 陈思颖 同学

2、文献汇报：小胶质细胞并非健康血脑屏障维持的必要条件，但PLX5622 改变脑血管内皮细胞的胆固醇代谢

主讲：张译文 同学

3、文献汇报：隐性动机指导适应性社会选择过程中的结构学习

主讲：付玉雪 同学

欢迎老师与同学们踊跃出席！

脑科学研究所

文献详细信息

1、题目：Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism

期刊名称：Neuron     IF: 14.4     SCI: Q1   中科院：一区

摘要：

Microglia, the resident immune cells of the central nervous system, are intimately involved in the brain’s most basic processes, from pruning neural synapses during development to preventing excessive neuronal activity throughout life. Studies have reported both helpful and harmful roles for microglia at the blood-brain barrier (BBB) in the context of disease. However, less is known about microglia-endothelial cell interactions in the healthy brain. To investigate the role of microglia at the healthy BBB, we used the colony-stimulating factor 1 receptor (CSF1R) inhibitor PLX5622 to deplete microglia and analyzed BBB ultrastructure, permeability, and transcriptome. Interestingly, we found that, despite their direct contact with endothelial cells, microglia are not necessary for maintenance of BBB structure, function, or gene expression in the healthy brain. However, we found that PLX5622 treatment alters brain endothelial cholesterol metabolism. This effect was independent from microglial depletion, suggesting PLX5622 has off-target effects on brain vasculature.

2、题目：Latent motives guide structure learning during adaptive social choice

期刊名称：Nature Human Behaviour IF: 17.3 SCI: Q1   中科院：一区

摘要：

Predicting the behaviour of others is an essential part of social cognition. Despite its ubiquity, social prediction poses a poorly understood generalization problem: we cannot assume that others will repeat past behaviour in new settings or that their future actions are entirely unrelated to the past. We demonstrate that humans solve this challenge using a structure learning mechanism that uncovers other people’s latent, unobservable motives, such as greed and risk aversion. In four studies, participants (N = 501) predicted other players’ decisions across four economic games, each with different social tensions (for example, Prisoner’s Dilemma and Stag Hunt). Participants achieved accurate social prediction by learning the stable motivational structure underlying a player’s changing actions across games. This motive-based abstraction enabled participants to attend to information diagnostic of the player’s next move and disregard irrelevant contextual cues. Participants who successfully learned another’s motives were more strategic in a subsequent competitive interaction with that player in entirely new contexts, reflecting that social structure learning supports adaptive social behaviour.