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主题：工作进展和文献报告

1、工作进展：多人公平决策中的情绪反应及情绪调节

主讲： 尚乐文 同学

2、工作进展：大脑白质结构-功能耦合的跨物种比较研究

主讲：张峻瑞 同学

3、文献汇报：运动通过骨骼肌源性细胞外囊泡介导小胶质细胞对β-淀粉样斑块的清除作用，从而改善阿尔茨海默病模型小鼠的认知功能

主讲：王亚童 同学

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脑科学研究所

文献详细信息

题目：Exercise alleviates cognitive dysfunction in Alzheimer's disease mice via skeletal muscle-derived extracellular vesicles that enhance plaque clearance by microglia

期刊信息：Nature Aging   IF: 19.6   SCI: Q1   中科院：一区

摘要：

Exercise confers cognitive benefits in Alzheimer's disease (AD), yet the underlying mechanisms remain incompletely understood. Skeletal muscle functions as an endocrine organ that secretes myokines which affect the homeostasis of extra-muscular organs, including the brain. Here we found that swimming exercise promotes secretion of skeletal muscle-derived extracellular vesicles (SKM-EVs), which are subsequently taken up via pinocytosis by microglia. Gain-of-function and loss-of-function experiments showed that exercise-induced SKM-EVs induce polarization of disease-associated microglia and enhance the clearance of amyloid-beta plaques. Furthermore, miR-378a-3p was identified as a key microRNA cargo in SKM-EVs, regulating lipid metabolism in disease-associated microglia by targeting p110α. Importantly, administration of extracellular vesicles derived from miR-378a-overexpressing myotubes alleviated cognitive impairment in AD mice. Together, our findings demonstrate that exercise-induced SKM-EVs could serve as a myokine, mediating communication from skeletal muscle to the brain, providing a potential exercise-mimicking therapeutic strategy for AD.