时间：4月16日 (周四)  18:00-20:00

地点：恕园28号楼205室

主题：工作进展和文献报告

1、工作进展：出生后发育早期少突胶质细胞前体细胞GluN3A亚基的作用及机制

主讲：李慧怡 同学

2、工作进展：帕罗西汀改善青春期创伤应激诱导的暴食行为的机制研究

主讲：周成 同学

3、文献汇报：星形胶质细胞 CB1 受体驱动中枢神经系统炎症性疾病中的血脑屏障崩塌

主讲：吴嘉蕾 同学

欢迎老师与同学们踊跃出席！

脑科学研究所

文献详细信息

题目：Astrocyte CB1 receptors drive blood-brain barrier disruption in central nervous system inflammatory disease

期刊名称：journal of neuroinflammation     IF: 10.1   SCI: Q1   中科院：一区

摘要：

Reactive astrocytes shape central nervous system (CNS) inflammation and participate in myelin damage and repair mechanisms in multiple sclerosis (MS). Through the activation of cannabinoid CB1 receptors (CB1R) expressed by neurons and oligodendrocyte lineage cells, endocannabinoid signaling restricts neurodegeneration and promotes remyelination in preclinical MS models. However, despite accumulating evidence that supports cell-specific roles for CB1R in brain physiology and pathology, the implications of astrocyte CB1R signaling in MS initiation and progression remain uncertain. Using complementary in vivo disease models, here we investigated the effects of targeted genetic deletion of astrocyte CB1R on the expression of MS-like pathology in mice. Interestingly, astrocyte-specific deletion of CB1R reduced demyelinating neuropathology, attenuated astrocyte reactivity and improved clinical deficits during the time-course of experimental autoimmune encephalomyelitis (EAE). Mice with astrocyte CB1R inactivation displayed unaltered oligodendrocyte populations both in EAE plaques and in lysolecithin-induced remyelinating spinal cord lesions, likely excluding that CB1R expressed by astroglial cells modulate myelin repair processes. Conversely, inactivation of CB1R in astrocytes restricted humoral and leukocyte parenchymal infiltration and reduced the expression of vascular effectors in EAE lesions. Finally, loss of blood-brain barrier (BBB) function induced by cortical microinjection of VEGF-A was less severe in astrocyte CB1R null mice. These results show that astrocyte CB1R signaling constitutes a significant pro-inflammatory mechanism in experimental MS and bring to light a deleterious role for endocannabinoid-mediated modulation of astroglial cells with potential implications in the etiopathology and therapy of neuroinflammatory disorders.