时间：5月21日 (周四)  18:00-20:00

地点：恕园28号楼205室

主题：工作进展和文献报告

1、工作进展：CCK信号在雌性焦虑易感性中的作用及机制

主讲：徐瑜苛 同学

2、文献汇报：外侧下丘脑的P物质调节小鼠暴食行为

主讲：胡馨娴 同学

3、文献汇报：猕猴在真实的与虚拟现实的空间导航任务操作过程中海马与眶额叶神经元对空间与任务的不同表征

主讲：徐余成 同学

欢迎老师与同学们踊跃出席！

脑科学研究所

文献详细信息

1、题目：Substance P in the lateral hypothalamic area regulates binge‐like eating behaviors in mice

期刊名称：PNAS IF:9.2 SCI: Q1   中科院：1区

摘要：Binge eating disorder (BED) is the most common type of eating disorder; however, the neural circuit mechanisms underlying BED remain elusive. Here, we report that tachykinin-­expressing neurons in the lateral hypothalamic area (LHTac1 neurons) are inhibited during binge-­like eating behaviors in mice. We identified LHTac1 neurons

as key mediators of binge-­like eating behaviors and reported that the LHTac1→ lateral

periaqueductal gray (LPAG) circuit is critical to the regulation of binge-­like eating behaviors. Moreover, Substance P (SP) released by LHTac1 neurons modulates binge­like eating behaviors by influencing the input of glutamate to LPAG cells, which receive projections from LHTac1 neurons. In summary, these findings point to the SP as a key node in BED circuits.

2、题目：Divergent neural representations of space and task between physical and virtual navigation in macaques

期刊信息：Nature Communications   IF：15.7     SCI：Q1     中科院：1区

摘要：Virtual reality is frequently used to explore the neural mechanisms of primate spatial cognition because it offers realistic simulations and precise experimental control. However, there remains a critical but untested assumption that virtual reality-based findings apply to real-world scenarios. We examined neural activity in the hippocampus and orbitofrontal cortex while two male macaque monkeys performed a spatial memory task in visually matched virtual and real environments. Monkeys learned the task efficiently in both settings. Neurons in both regions showed richer allocentric spatial representations in the real compared to the virtual environment, with individual cells unpredictably adjusting their specific responses. Cross-condition analyses revealed orthogonal population representations of task phases across the two environments. These results highlight the importance of studying monkeys in real-world settings, where they can fully express their behaviors and interact freely with their surroundings, to uncover the true neural basis of primate spatial cognition.