1、工作进展：抑郁亚临床群体概率反转学习能力的静息态脑功能网络研究

主讲：刘冠初 同学

2、文献汇报：猕猴前额叶皮层整合多种成分以进行工作记忆的元认知判断

主讲：范宇 同学

3、文献汇报：对音乐乐句结构的神经与行为跟踪可在缺乏时间规律性的情况下发生

主讲：罗婧荷 同学

欢迎老师与同学们踊跃出席！

脑科学研究所

文献详细信息

1、题目：Macaque prefrontal cortex integrates multiple components for metacognitive judgments of working memory

期刊名称：Neuron   IF: 16.76   SCI: Q1   中科院：一区

摘要：The ability to evaluate one’s own memory is known as metamemory. Whether metamemory is inherent to memory strength or requires additional computation in the brain remains largely unknown. We investigated the metacognitive mechanism of working memory (WM) using two-photon calcium imaging in the prefrontal cortex (PFC) of macaque monkeys, memorizing spatial sequences of varying difficulties. In some trials, after viewing the sequence, monkeys could opt out of retrieval for a smaller reward, reflecting their confidence in WM (meta-WM). We discovered that PFC neurons encoded WM strength by jointly representing the remembered locations and their associated uncertainties. Additional factors—trial history and arousal—encoded in baseline activity also predicted opt-out decisions, serving as cues for meta-WM. We further identified a code for meta-WM itself that integrated WM strength with these cues. Thus, the PFC neural geometry implements metacognitive computations, integrating WM strength with cues into a meta-WM signal to guide behavior.

2、题目：Neural and Behavioral Tracking of Musical Phrases Occurs Without Temporal Regularity

期刊名称：European Journal of Neuroscience   IF：2.4   SCI：Q3   中科院：3区

摘要：When listening to music or speech, people naturally divide continuous sound streams into segments for easier and faster processing of information. The segmentation boundaries are not random. Listeners agree on the points of segmentation, which are consistent with arbitrary rules—for example, those established by music theory—and often occur at regular time intervals. It is thus unclear whether phrase tracking relies on understanding of musical structure or merely on temporal predictability. To address this, we examined how non-musicians process both regular (temporally predictable) and irregular musical phrases derived from J.S. Bach's compositions. This approach preserved authentic musical structure while manipulating temporal predictability. We also included control stimuli matched in acoustic properties but lacking musical structure. Behavioral and EEG measures revealed that listeners could accurately detect phrase boundaries in both regular and irregular conditions. Neural activity, indexed by an increase in low-frequency EEG power, reflected the tracking structural boundaries regardless of temporal regularity. These findings demonstrate that musical segmentation depends fundamentally on implicit understanding of musical structure, rather than on temporal predictability alone.