时间：7月2日 (周四)  18:00-20:00

地点：恕园28号楼205室

主题：工作进展和文献报告

1、工作进展：精神分裂症的思维形式障碍的数字表型构建及神经机制研究   

主讲：乔艺硕 同学

2、工作进展：小胶质细胞移植替换治疗渐冻症的机制研究

主讲：盛世红 同学

3、文献汇报：厌恶反转学习过程中特质焦虑与隐藏状态推断的关联

主讲：聂淑琴 同学

欢迎老师与同学们踊跃出席！

文献详细信息

题目： Trait anxiety is associated with hidden state inference during aversive reversal learning

期刊名称：Nature Communications    IF: 15.7  SCI: Q1  中科院：1区TOP 

摘要：Updating beliefs in changing environments can be driven by gradually adapting expectations or by relying on inferred hidden states (i.e. contexts), and changes therein. Previous work suggests that increased reliance on context could underly fear relapse phenomena that hinder clinical treatment of anxiety disorders. We test whether trait anxiety variations in a healthy population influence how much individuals rely on hidden-state inference. In a Pavlovian learning task, participants observed cues that predicted an upcoming electrical shock with repeatedly changing probability, and were asked to provide expectancy ratings on every trial. We show that trait anxiety is associated with steeper expectation switches after contingency reversals and reduced oddball learning. Furthermore, trait anxiety is related to better fit of a state inference, compared to a gradual learning, model when contingency changes are large. Our findings support previous work suggesting hidden-state inference as a mechanism behind anxiety-related to fear relapse phenomena.