时间：9月17日 (周四)  18:00-20:00

地点：恕园28号楼205室

主题：工作进展和文献报告

1、文献汇报：儿童期稳定的直觉与审慎亲社会性的发展（Stable intuition and the rise of deliberative prosociality in childhood）

主讲：周源 同学

2、文献汇报：精神分裂症的语言网络功能异常与思维形式障碍（Language Network Dysfunction and Formal Thought Disorder in Schizophrenia  ）

主讲：柳可 同学

3、文献汇报：小胶质细胞的昼夜节律以性别特异性方式介导早期生命突触发育（Circadian rhythms in microglia mediate early life synaptic development in a sex-specific manner

）

主讲：陆洁莹 同学

4、工作进展：机会与结果公平决策过程中人际信息对即时情绪的调节

主讲：付玉雪 同学

欢迎老师与同学们踊跃出席！

脑科学研究所

文献详细信息：

1、题目：Stable intuition and the rise of deliberative prosociality in childhood

期刊名称：Nature Human Behaviour

IF：17.5

SCI: Q1

中科院：1区

摘要：

We examine how social behaviours emerge and stabilize across childhood. A sample of 537 Italian-speaking children (3-10 years) were randomly assigned to respond under time pressure (intuitive) or time delay (deliberative) in social decision tasks (Public Goods, Dictator, Ultimatum, Deception and Moral Dilemmas). Factor analysis identified three latent dimensions: Prosociality (cooperative, altruistic and honest actions), Social Optimism (beliefs about others’ cooperation) and Acquiescence (tendency to accept offers). Intuitive responses were more prosocial than deliberative ones in early childhood (β = 0.66; 95% CI = (0.35, 0.97)), but this difference diminished with age (β = −0.11; 95% CI = (−0.18, −0.05)). We found no evidence that Social Optimism varied across age or decision mode, whereas Acquiescence declined with age (β = −0.14; 95% CI = (−0.19, −0.10)). These

findings suggest a developmental shift whereby prosocial behaviour is initially driven by intuitive responses and gradually becomes embedded within reflective, deliberative decision-making systems, as cooperative dispositions stabilize across childhood.

2、题目：Language Network Dysfunction and Formal Thought Disorder in Schizophrenia

期刊名称：Schizophrenia Bulletin

IF: 6.4 

SCI: Q1  

中科院：1区

摘要：Pathophysiological inquiries into schizophrenia require a consideration of one of its most defining features: disorganization and impoverishment in verbal behavior. This feature, often captured using the term Formal Thought Disorder (FTD), still remains to be one of the most poorly understood and understudied dimensions of schizophrenia. In particular, the large-scale network level dysfunction that contributes to FTD remains obscure to date. Study Design: In this narrative review, we consider the various challenges that need to be addressed for us to move towards mapping FTD (construct) to a brain network level account (circuit). Study Results: The construct-to-circuit mapping goal is now becoming more plausible than it ever was, given the parallel advent of brain stimulation

and the tools providing objective readouts of human speech. Notwithstanding this, several challenges remain to be overcome before we can decisively map the neural basis of FTD. We highlight the need for phenotype refinement, robust experimental designs, informed analytical choices, and present plausible targets in and beyond the Language Network for brain stimulation studies in FTD. Conclusions: Developing a therapeutically beneficial pathophysiological model of FTD is a challenging endeavor, but holds the promise of improving interpersonal communication and reducing social disability in schizophrenia. Addressing the issues raised in this review will be a decisive step in this direction.

3、题目：Circadian rhythms in microglia mediate early life synaptic development in a sex-specific manner

期刊名称：Cell Reports

IF: 6.9

SCI: Q1

中科院：1区

摘要：Children today experience widespread circadian disruption from nighttime screen use and irregular sleep, yet how internal clocks shape brain development is unclear. Adolescence is a critical window when synaptic connectivity is refined, in part by microglia that engulf synaptic elements. Here, in adolescent mice, we show that hippocampal microglia exhibit diurnal transcriptional rhythms, with synaptic pruning gene expression peaking during the rest phase. Inducible deletion of the core clock gene Bmal1 in microglia in early life abolishes these rhythms and alters developing hippocampal synapses in a sex-dependent manner. In males, clock disruption increases synapse engulfment, reduces dendritic spine density, and decreases synaptic connectivity; females show similar reductions in synaptic connectivity without overt postsynaptic structural changes. Microglial clock disruption also induces broad, sex-specific changes in synapse-related gene expression that overlap with neurodevelopmental disorder pathways and lead to impaired memory and sociability, indicating microglial clocks as key regulators of developmental synapse refinement.