时间：9月24日 (周四)  18:00-20:00

地点：恕园28号楼205室

主题：工作进展和文献报告

1、文献汇报：猕猴虚拟现实环境导航的皮层内脑机接口（Intracortical brain-computer interface for navigation in virtual reality in macaque monkeys）

主讲：范宇 同学

2、文献汇报：杏仁核应激反应系统调控青春期和成年小鼠对负性应激诱导的远期抑郁的不同易感性（Amygdala stress-responsive ensembles mediate distinct susceptibility to negative stress-induced remote depression in adolescent and adult mice）

主讲：胡馨娴 同学

3、剑桥暑期项目分享&工作进展汇报：公平声誉对观察者社会交往的影响

主讲：文艺谚 同学

4、文献汇报：灵长类腹侧纹状体作为桥接选项评估与动作选择的神经枢纽的作用（Role of the primate ventral striatum as a neural hub bridging option valuation and action selection）

主讲：胡涛 同学

欢迎老师与同学们踊跃出席！

脑科学研究所

文献详细信息：

1、题目：Intracortical brain-computer interface for navigation in virtual reality in macaque monkeys

期刊名称：Science Advances  IF: 13.9  SCI: Q1  中科院：1区

摘要：We present an innovative intracortical brain-computer interface (BCI) to bridge the gap between laboratory settings and real-world applications. This BCI approach introduces three key advancements. First, we used neural signals from three macaque brain regions—primary motor, dorsal, and ventral premotor cortex—enabling precise and flexible decoding of real-time three-dimensional (3D) sphere/avatar velocities. Second, we developed a realistic, immersive 3D virtual reality setup with dynamic camera tracking, allowing continuous navigation and obstacle avoidance that closely mimic real-world scenarios. Last, our BCI approach is very well suited for use by paralyzed patients, featuring a brief passive fixation without overt movements and closed-loop operation without retraining of the decoder during online decoding, relying on the user's neural plasticity and the decoder's robust generalization across tasks. Our BCI adapted to different environments, targets, and obstacles, illustrating its potential to substantially enhance the quality of life for paralyzed patients by enabling natural, reliable, and flexible control in complex settings.

2、题目：Amygdala stress-responsive ensembles mediate distinct susceptibility to negative stress-induced remote depression in adolescent and adult mice

期刊名称：Cell Reports  IF: 7.7  SCI: Q1  中科院：1区

摘要：Adolescent stress increases susceptibility to adult depression, potentially by encoding negative memories in stress-responsive neuronal ensembles, though the mechanisms remain unclear. In this study, we use a social defeat stress model with Tet-off labeling to examine the effects of short-term stress during adolescence and adulthood on behavior and cellular changes. Adolescent stress generates denser, more excitable stress-responsive neuronal ensembles in the basolateral amygdala (BLA) compared to adult stress, suggesting persistent traces of early-life stress that heighten remote depression risk. Adolescent mice display underdeveloped, hypoactive parvalbumin (PV) interneurons in the BLA, further suppressed by microglial phagocytic activity. Bidirectional modulation of BLA stress-responsive neuronal ensembles or PV neurons significantly alters depression-like behaviors. Overall, our findings indicate that BLA stress-responsive neuronal ensembles mediate differences in depression susceptibility between adolescent and adult stressed mice, with microglial dysfunction impairing PV neuron inhibitory control. These insights offer potential targets for early intervention in adult depression.

3、题目：Role of the primate ventral striatum as a neural hub bridging option valuation and action selection

期刊名称：Nature Communication  IF: 15.7  SCI: Q1  中科院：1区

摘要：Making appropriate decisions relies on the brain's capacity to evaluate the expected outcomes of available options and select the most rewarding action. The ventral striatum and midbrain dopamine neurons have been implicated in the option valuation process, consistent with the brain's reinforcement learning theory in which these brain structures encode and update value representations of expected outcomes. Extending beyond this framework, we found that the dopamine-ventral striatum system plays a more proactive role in action selection. We recorded single-unit activity from ventral striatum neurons in macaque monkeys as they sequentially evaluated an option, decided whether to perform an action to choose it, and expressed that motor action. The activity of these neurons initially reflected the value of the option but gradually shifted to reflect monkey's action selection, as if the ventral striatum translates the value information into the action. Moreover, optogenetic facilitation of dopamine input to the ventral striatum as well as electrical stimulation of this region altered monkey's action selection. Our findings reveal a previously unappreciated function of the ventral striatum as a neural hub that bridges option valuation and action selection, and demonstrate the contribution of dopamine in the process leading to action selection within this region.