时间：11月13日 (周四)  18:00-20:00

地点：恕园28号楼205室

主题：文献报告

1、文献汇报：星形胶质细胞起源的CHI3L1信号损害脱髓鞘海马的神经发生与认知功能

主讲：吴嘉蕾 同学

文献详细信息

题目：Astrocyte-derived CHI3L1 signaling impairs neurogenesis and cognition in the demyelinated hippocampus

期刊信息：Cell Reports IF：6.9 SCI：Q1 中科院：一区

摘要：

Cognitive dysfunction is a feature in multiple sclerosis (MS), a chronic inflammatory demyelinating disorder. A notable aspect of MS brains is hippocampal demyelination, which is closely associated with cognitive decline. However, the mechanisms underlying this phenomenon remain unclear. Chitinase-3-like (CHI3L1), secreted by activated astrocytes, has been identified as a biomarker for MS progression. Our study investigates CHI3L1’s function within the demyelinating hippocampus and demonstrates a correlation between CHI3L1 expression and cognitive impairment in patients with MS. Activated astrocytes release CHI3L1 in reaction to induced demyelination, which adversely affects the proliferation and differentiation of neural stem cells and impairs dendritic growth, complexity, and spine formation in neurons. Our findings indicate that the astrocytic deletion of CHI3L1 can mitigate neurogenic deficits and cognitive dysfunction. We showed that CHI3L1 interacts with CRTH2/receptor for advanced glycation end (RAGE) by attenuating β-catenin signaling. The reactivation of β-catenin signaling can revitalize neurogenesis, which holds promise for therapy of inflammatory demyelination.

2、文献汇报：催产素信号调控生命早期的母婴导朝向行为

主讲：鞠滢蔚 同学

文献详细信息

题目：Oxytocin signaling regulates maternally directed behavior during early life

期刊信息：Science IF: 45.8 SCI: Q1 中科院：一区

摘要：

The role of oxytocin (OT) in early-life social behavior remains poorly understood. We found that maternal separation in mouse pups recruits hypothalamic OT neurons, which regulate pup vocalizations upon reunion. Using a novel transcranial optogenetic approach, we demonstrate that OT neuron activity during separation selectively shapes the dynamics and contextual patterning of ultrasonic vocalizations in a sex-specific manner. This study establishes a critical role for infant OT signaling in social communication and provides a technical platform for investigating neural circuit development.

3、文献汇报：基底前脑-腹侧被盖区的兴奋性投射介导厌食样行为表型

主讲：胡馨娴 同学

文献详细信息

题目：An excitatory projection from the basal forebrain to the ventral tegmental area that underlies anorexia-like phenotypes

期刊信息：Neuron IF：15.0 SCI：Q1 中科院：一区

总结：

Maladaptation in balancing internal energy needs and external threat cues may result in eating disorders.However, brain mechanisms underlying such maladaptations remain elusive. Here, we identified that the basal forebrain (BF) sends glutamatergic projections to glutamatergic neurons in the ventral tegmental area (VTA) in mice. Glutamatergic neurons in both regions displayed correlated responses to various stressors. Notably, in vivo manipulation of BF terminals in the VTA revealed that the glutamatergic BF→VTA circuit reduces appetite, increases locomotion, and elicits avoidance. Consistently, activation of VTA glutamatergic neurons reduced body weight, blunted food motivation, and caused hyperactivity with behav ioral signs of anxiety, all hallmarks of typical anorexia symptoms. Importantly, activation of BF glutamatergic terminals in the VTA reduced dopamine release in the nucleus accumbens. Collectively, our results point to overactivation of the glutamatergic BF→VTA circuit as a potential cause of anorexia-like phenotypes involving reduced dopamine release.

4、文献汇报：猕猴额叶皮层工作记忆空间序列的心理编程

主讲：徐余成 同学

文献详细信息

题目：Mental programming of spatial sequences in working memory in the macaque frontal cortex

期刊信息：Science IF：45.8   SCI：Q1   中科院：一区

摘要：

How the brain mentally sorts a series of items in a specific order within working memory (WM) remains largely unknown. We investigated mental sorting using high-throughput electrophysiological recordings in the frontal cortex of macaque monkeys, who memorized and sorted spatial sequences in forward or backward orders according to visual cues. We discovered that items at each ordinal rank in WM were encoded in separate rank-WM subspaces and then, depending on cues, were maintained or reordered between the subspaces, accompanied by two extra temporary subspaces in two operation steps. Furthermore, the cue activity served as an indexical signal to trigger sorting processes. Thus, we propose a complete conceptual framework, where the neural landscape transitions in frontal neural states underlie the symbolic system for mental programming of sequence WM.

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